Drug delivery through nails (Transungual drug delivery) is considered to be highly propitious for treating nail disorders as systemic therapy is associated with severe systemic side effects like hepatic toxicity, gastric upset, hematological disorders, drug-drug interactions etc. However, the efficacy of topical therapy is limited due to minimal drug permeability through the nail plate, therefore, there is a need of a formulation which can easily penetrate the nail plate along with which provides safety, efficacy and compliance. The Current review focuses on the Anatomy of a human nail, Different type of nail disorders, Factors which affect drug permeation through the nail along with the different techniques which are available to improve drug permeation through nails and the latest trends which are available nowadays for transungual drug delivery. In this article nail lacquers, which past recently striked the formulation field along with some of the limitations of transungual drug delivery has been discussed in brief.
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